VI EWDSy – HIV Session & THINPAD Dissemination


We are pleased to announce that during the  VI EWDSy a special session has been planned. It will be dedicated to THINPAD Dissemination, including lectures about the last year developement in HIV research and new approaches to fight Antiretroviral Drug Resistance



9:55-10:20 Mattia MoriTHINPAD: Targeting the HIV-1 Nucleocapsid Protein to fight Antiretroviral Drug Resistance
10:25-10:55 Coffee Break
10:55-11:40 Vincenzo Summa From hit to Drug: the discovery of Isentress™ , the first in class HIV-integrase inhibitor
11:45-12:30 Yves MelyDevelopment and application of screening assays to disclose molecules targeting HIV-1 reverse transcriptase and nucleocapsid protein

Romano SilvestriTwenty years of sulfone non-nucleoside HIV-1 reverse transcriptase inhibitors

33 months- THINPAD Meeting

AGENDA– 33 months- THINPAD Meetingthinpad
Date & Time: May 19th-20th 2016
Location: Certosa di Pontignano Siena



19th  May- THINPAD Meeting -1st session

16:00-16:40 Welcome Coffee
16:45-17:00 THINPAD Coordinator– State of Art of the Project
17:00-17:20 UNIStra – NC-inh assay & MoA
17:20-17:45 IDIBAPS – EMSA results
17:45:18:05 UNISI Monocyle & Bicycle results
19:00- THINPAD Networking Dinner


20th MayTHINPAD Meeting 2nd session

9:00-9:25 Michela Renzulli – Administrative Management
9:25-9:45 Virostatics -Toxicity assay
9:45-10:05 UNISI – Aminothiazoles NCIs synthesis & Structure Activity Relationship results
10:05-10:25 IRBM –  Pyrimidines NCIs  synthesis & Structure Activity Relationship results & Structure Toxicity Relationship Results
10:25-11:05 Discussion (IP issues, publishable material, other…)
11:05-11:25 Prof Gatell– Antiretroviral Therapy in the 2020 Horizon: Why we still need new HIV targets ?
11:25- Conclusion an Future Meeting
12:00 Lunch

IRNCAS 10th International Retroviral Nucleocapsid protein and Assembly Symposium

The Symposium will be held in Montpellier on 18-21 September 2016

The topic of the IRNCAS International Symposium is the retroviral nucleocapsid protein (NC) and its Gag precursor, a polyprotein responsible for the viral assembly.

This symposium represents an important opportunity in getting together the specialists and generating new collaborations and multidisciplinary studies (biophysics, biochemistry, virology, cellular biology, biomedicine and biophotonics). During the last 15 years, these collaborations have provided important progresses in the insight into the molecular and cellular mechanisms of action of the HIV-1 nucleocapsid and its Gag precursor, making them promising targets in the design of inhibitors against the AIDS epidemics.

This 10th edition should encourage the continuation of our collaborative network in order to enlighten the structural and functional properties of the NC domain of Gag during virus assembly in the host cell.

“Special attention will be given to :

  • RNA-NC interactions
  • Gag and cell factors interactions (membrane lipids and cellular proteins)
  • Gag and NC chaperone properties
  • The impact of the biophysical methods, notably of the high resolution microscopy and the NMR, on the understanding of Gag assembly
  • Therapeutic strategies targeting HIV-1 NC and Gag assembly.

The major topics discussed during this Symposium are focused on the HIV-1 nucleocapsid and on the retroviral Gag proteins, however other nucleocapsid of viruses causing human pathologies (HTLV, Hepatitis and Influenza) will be also considered.”

List of invited speakers:

Keynote speakers:

Bieniasz Paul*, Rockfeller University, NY, USA

Lamb Don*, University of Munich, Germany

Invited speakers:

Berkhout Ben, AMC, University of Amsterdam, Netherland
Boris-Lawrie Kathleen,University of Minnesota, Columbus, USA
Botta Maurizio, University of Siena, Italy
Bouamr Fadila, NIAID, NIH, Bethesda, USA
Briggs John, European Molecular Biology Laboratory, Germany
Cimarelli Andrea, INSERM & ENS Lyon, France
Freed Eric, HIV Drug Resistance Program, NCI-Frederick, USA
Favard Cyril, CNRS, CPBS Montpellier, France
Gatto Barbara, University of Padova, Veneto, Italy
Lever Andrew, University of Cambridge, UK
Marquet Roland, CNRS & IBMC, Strasbourg, France
Mély Yves, Université de Strasbourg & CNRS, France
Mirambeau Gilles, UPMC & Hospital Clinic-IDIBAPS, France & Spain
Milhiet Pierre-Emmanuel, CBS Montpellier, France
Mouland Andrew, Mc Gill University, Montreal, Canada
Müller Barbara, University Hospital, Heidelberg, Germany
Muriaux Delphine, CNRS, CPBS Montpellier, France
Musier-Forsyth Karin, Ohio State University, Columbus, USA
Ohlmann Theophile, INSERM & ENS Lyon, France
Parent Leslie, Penn State College of Medicine, Hershey, USA
Rein Alan, HIV Drug Resistance Program, NCI-Frederick, USA
de Rocquigny Hugues, CNRS & Université de Strasbourg, France
Saad Jamil, University of Alabama, Birmingham, USA
Summers Michael, HHMI & University of Maryland, Baltimore, USA
Schwartz Olivier, Institut Pasteur, France
Tisné Carine, CNRS & Université Paris Descartes, France
Williams Mark, Northeastern University, Boston, USA

Scientific committee:

Ben Berkhout, University of Amsterdam, Netherlands
Andrew Mouland, McGill University, Canada
Yves Mély, France, Université de Strasbourg, France
Mark Williams, Northeastern University, Boston, USA
Leslie Parent, Penn State University, Hershey, USA
Mike Summers, JHopkins University, Baltimore, USA
Fadila Bouamr, NIH, Bethesda, USA
Gilles Mirambeau, IDIBAPS, Barcelona, Spain


This 10th edition is co-organized by:

D. Muriaux (Montpellier, FR), H. de Rocquigny (Strasbourg, FR),C. Favard (Montpellier, FR), C. Mariani-Floderer (Montpellier, FR), E.O Freed (NIH Frederick, USA), K. Musier-Forsyth (Ohio, USA).    



May 15th – 19th 2016. Certosa di Pontignano, Siena (Italy)

The University of Siena is organizing the “Sixth European Workshop in Drug Synthesis” (VI EWDSy), to be held, from May 15th to 19th 2016, in Certosa di Pontignano, on the outskirt of the beautiful city of Siena, in Tuscany.

This year, the workshop will be focused on novel synthetic procedures in medicinal chemistry, HIV research, neglected diseases and ADMET. The aim of this unique event is to provide a fertile ground for young chemists to share and exchange knowledge.

These topics will be covered by lectures of cutting-edge researchers in the mornings and dedicated sessions in the afternoon.
There will also be the possibility to attend to short talks from promising young researchers and shotgun presentations from selected posters.

For more info about the event please visit


The following eminent scientists already accepted to lecture:


Alan Kozikowski – University of Illinois, Chicago (USA)

Christian Ottmann – Eindhoven University of Technology (Netherlands)

Dario Neri – ETH (Switzerland)

Dennis Liotta – Emory University (USA)

Dieter Schinzer – University of Magdeburg (Germany)

Fernando Albericio – IRB, Barcelona (Spain)

Helena Danielson – Uppsala University (Sweden)

Hugo Kubinyi – BASF SE and University of Heidelberg (retired) (Germany)

Karl-Heinz Altmann – ETH Zurich (Switzerland)

Katherine L. Seley-Radtke – University of Maryland, Baltimore Co. (USA)

Kevin Burgess – Texas A & M University (USA)

Magid Abou-Gharbia – Moulder Center for Drug Discovery Research, Temple University (USA)

Maria José Camarasa – Consejo Superior de Investigaciones Científicas (Spain)

Markus Kalesse – Leibniz Universität Hannover (Germany)

Matteo Zanda – University of Aberdeen (UK)

Paolo Melchiorre – Institute of Chemical Research of Catalonia (Spain)

Stephen Hanessian – University of Montreal (Canada) and University of California, Irvine (USA)

Stephen Neidle – University College, London (UK)

Ulrike Holzgrabe – University of Würzburg (Germany)

William Jorgensen – Yale University (USA)

Youssef Bennani – Domain Therapeutics and Vertex Pharmaceuticals (Canada)

Yves Mely – University of Strasbourg (France)



Participation to EWDSy is limited to 65 attendants.

New Open Access Publication

New Open Access Publication

Functional and Structural Characterization of 2-Amino-4-phenylthiazole Inhibitors of the HIV-1 Nucleocapsid Protein with Antiviral Activity– 

Mattia Mori , Alessandro Nucci , Maria Chiara Dasso Lang , Nicolas Humbert , Christian BoudierFrancois Debaene , Sarah Sanglier-Cianferani , Marjorie Catala , Patricia Schult-Dietrich ,Ursula Dietrich , Carine Tisné , Yves Mely , and Maurizio Botta

ACS AuthorChoice – This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

Partner 1-UNISI- Dissemination Activity



November 10th 2014 – (Padova, Italy)- Workshop on Inhibitors of HIV‐1 nucleocapsid protein- Dr Mattia Mori, invited speaker. Lesson Title: “Computational design of inhibitors of the HIV‐1 Nucleocapsid protein, a desirable target for future anti-HIV-1 therapies”